Welcome to CAB at St. Jude

The CAB Epigenetics Group focuses on helping researchers answer biological questions related to regulation through epigenetic mechanisms using the best available tools. We are also interested in establishing new analytic pipelines to enhance researching practices of St. Jude investigators.


We mainly expereinced on areas:

  • Cancer Biology
  • Developmental Biology
  • Innate Immunology

We categorized Epigenetics Analyses briefly into three major topics:

  1. Regulation discovery: Discover and predict regulation relationship using NGS data such as ChIP-Seq and intergrative with other data.
  2. Chromatin state: Chromatin accessibility can be measure by method such as ATAC-seq, DNase-seq. Together with motif database, transcription factors (TFs) likely to associated with differential accessible regions can be identified.
  3. 3D Genome: Thanks to Chromosome conformation capture(3C) technologies or 3C-based methods, people are able to study the 3D structure of chromatin. Topological association domains (TADs), Compartments, Chromatin loops were all found could regulated gene’s functions.

Technologies and methods

The CAB Epigenetics is primarily a bioinformatic group that uses a wide range of genomic, bioinformatic, and statistical methods including:

  • ChIP-Seq
  • ATAC-Seq/scATAC
  • RNA-Seq/SLAM-Seq/scRNA
  • HiC/HiCHIP/PLAC-Seq/CaptureC

Joining St. Jude

If you are interested in joining please go to the recruitment page.

Funding

We are grateful for funding from the National Cancer Institute at National Institute of Health

News

Oct 19th 2021

New paper! Wang et al. 2021 published in Life Sci. Alliance: PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands. Kudo to Wojciech, first co-first author with St. Jude PIs

Aug 24th 2021

New paper! Xu et al. 2021 published in Genome Bio.: Acute depletion of CTCF rewires genome-wide chromatin accessibility. Press Release

Jun 8th 2021

New paper! Montefiori et al. 2021 published in Cancer Discov.: Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage Ambiguous Stem Cell Leukemia

Jun 4th 2021

New paper! Zong et al. 2021 published in J. Exp. Med.: Foxp3 Enhancers Synergize to Maximize Regulatory T Cell Suppressive Capacity

Apr 5th 2021

New paper! Chen et al. 2021 published in Nat Genet, Dr. Mohamed Nadhir Djekidel(co-first) deciphers the Mysterious Roles of PRC Complexes in Histone Modification

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