Welcome to CAB at St. Jude

The CAB Genetics Group focuses on the association of inherited or acquired genetic variations with clinical or phenotypic traits in humans. We are also interested in establishing new bioinformatic and statistical pipelines to enhance researching practices of St. Jude investigators.

We mainly focus on these areas:

  • Germline pediatric cancer
  • Pediatric neurogenetics
  • Annotations and interpretation of non-coding variants

We categorized Genetics Analyses briefly into three major topics:

  • Individual studies: ACMG/AMP 2015 classification of germline variants.
  • Family studies: Segregation and filtering approaches for novel variant discovery.
  • Cohort studies: Testing and application of published methods for single variant, gene-based, and pathway-level analyses of large cohorts.

Technologies and methods

The CAB Genetics Group is primarily a statistical genetics/bioinformatic group that uses a wide range of genomic, bioinformatic, and statistical methods including:

  • Amplicon sequencing
  • WES
  • WGS
  • RNA-Seq

Joining St. Jude

If you are interested in joining please go to the recruitment page.


Jan 2024

New papers! Yang et al. 2024; NucleicAcidsRes.;Mondal et al. 2023; CancerRes;Ho et al. 2023; JClinInvest;Barajas et al. 2023; Blood;Kamens et al. 2023; NatCommun;Matsui et al. 2023; NatCommun;Searcy et al. 2023; NatCommun;Tian et al. 2023; Oncogene;Wright et al. 2023; Proc.Natl.Acad.Sci.;Surman et al. 2023; Viruses;Ranjit et al. 2024; DrugResist.Updates;

Jan 2023

New papers! Zhao et al. 2022; NatCommun;Singh et al. 2022; Sci.Transl.Med.;Jiao et al. 2023; CellReports;Wang et al. 2023; Sci.Adv.; Kudo to Nadhir, co-first author Hyle et al. 2023; GenomeBiol.; Press Release

July 1th 2022

New papers! Dickerson et al. 2022; BloodCancerDiscovery;Zhao et al. 2022; JNCI;Drosos et al. 2022; MolecularCell;Graca et al. 2022; NatCommun; Kudo to Wojciech, co-first author Qi et al. 2022; JPathol

Oct 19th 2021

New paper! Wang et al. 2021 published in Life Sci. Alliance: PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands. Kudo to Wojciech, first co-first author with St. Jude PIs

Aug 24th 2021

New paper! Xu et al. 2021 published in Genome Bio.: Acute depletion of CTCF rewires genome-wide chromatin accessibility. Press Release

... see all News