Welcome to CAB at St. Jude

The CAB Genomics Group focuses incorporate state-of-art analytic approaches to understand how the tumorigenesis and relevant biological processes shaped by genomic variations. The team is also of interests in establishing genomics analytic pipelines to support the work of St. Jude investigators.


We mainly focus on these areas:

  • Cancer genomics
  • Germline genomics
  • Metagenomics
  • Comparative/Evolutionary genomics
  • Viral genomics

We categorized Genomics Analyses briefly into several major topics:

  • Cancer Genomics: Study of the totality of DNA sequence variations between tumor cells and normal cells
  • Germline Genomics: Different from acquired somatic mutations, occurs in reproductive cells (sperm, egg) and inherits to the offspring
  • Meta-genomics: 16S Operational Taxonomic Units(OTU) analysis
  • Comparative/Evolutionary genomics: Guided/de novo Genome assembly, gene annotation, evolution analysis
  • Viral genomics: Viral genome assembly, annotation, phylogenetic history reconstruction

Technologies and methods

The CAB Genomics Group is primarily a bioinformatic group that uses a wide range of genomic, bioinformatic, and statistical methods including:

  • Whole exome sequencing
  • Long read sequencing (Pacbio, 10X and Oxford Nanopore)
  • Amplicon sequencing (Customized Capture, 16S rRNA, CRISPR screening)

Joining St. Jude

If you are interested in joining please go to the recruitment page.

News

Oct 19th 2021

New paper! Wang et al. 2021 published in Life Sci. Alliance: PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands. Kudo to Wojciech, first co-first author with St. Jude PIs

Aug 24th 2021

New paper! Xu et al. 2021 published in Genome Bio.: Acute depletion of CTCF rewires genome-wide chromatin accessibility. Press Release

Jun 8th 2021

New paper! Montefiori et al. 2021 published in Cancer Discov.: Enhancer Hijacking Drives Oncogenic BCL11B Expression in Lineage Ambiguous Stem Cell Leukemia

Jun 4th 2021

New paper! Zong et al. 2021 published in J. Exp. Med.: Foxp3 Enhancers Synergize to Maximize Regulatory T Cell Suppressive Capacity

Apr 5th 2021

New paper! Chen et al. 2021 published in Nat Genet, Dr. Mohamed Nadhir Djekidel(co-first) deciphers the Mysterious Roles of PRC Complexes in Histone Modification

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