Welcome to CAB at St. Jude
The CAB Genomics Group focuses incorporate state-of-art analytic approaches to understand how the tumorigenesis and relevant biological processes shaped by genomic variations. The team is also of interests in establishing genomics analytic pipelines to support the work of St. Jude investigators.
We mainly focus on these areas:
- Cancer genomics
- Germline genomics
- Metagenomics
- Comparative/Evolutionary genomics
- Viral genomics
We categorized Genomics Analyses briefly into several major topics:
- Cancer Genomics: Study of the totality of DNA sequence variations between tumor cells and normal cells
- Germline Genomics: Different from acquired somatic mutations, occurs in reproductive cells (sperm, egg) and inherits to the offspring
- Meta-genomics: 16S Operational Taxonomic Units(OTU) analysis
- Comparative/Evolutionary genomics: Guided/de novo Genome assembly, gene annotation, evolution analysis
- Viral genomics: Viral genome assembly, annotation, phylogenetic history reconstruction
Technologies and methods
The CAB Genomics Group is primarily a bioinformatic group that uses a wide range of genomic, bioinformatic, and statistical methods including:
- Whole exome sequencing
- Long read sequencing (Pacbio, 10X and Oxford Nanopore)
- Amplicon sequencing (Customized Capture, 16S rRNA, CRISPR screening)
Joining St. Jude
If you are interested in joining please go to the recruitment page.
News
May 2025New papers! Graham et al. 20; CancerResearchCommunications;Abu-Zaid et al. 20; CellReportsMedicine;Honnell et al. 20; Development;Zhang et al. 20; GenomeBiology;He et al. 20; JournalofExperimentalMedicine;Thomas et al. 20; Leukemia;Mittal et al. 20; NatCommun;Hughes et al. 20; NatNeurosci;Lim et al. 20; PLOSBiology;Norrie et al. 20; DevelopmentalCell;Hyle et al. 20; GenomeBiol;Yang et al. 20; GenomeBiol;
New papers! Yang et al. 2024; NucleicAcidsRes.;Mondal et al. 2023; CancerRes;Ho et al. 2023; JClinInvest;Barajas et al. 2023; Blood;Kamens et al. 2023; NatCommun;Matsui et al. 2023; NatCommun;Searcy et al. 2023; NatCommun;Tian et al. 2023; Oncogene;Wright et al. 2023; Proc.Natl.Acad.Sci.;Surman et al. 2023; Viruses;Ranjit et al. 2024; DrugResist.Updates;
New papers! Zhao et al. 2022; NatCommun;Singh et al. 2022; Sci.Transl.Med.;Jiao et al. 2023; CellReports;Wang et al. 2023; Sci.Adv.; Kudo to Nadhir, co-first author Hyle et al. 2023; GenomeBiol.; Press Release
New papers! Dickerson et al. 2022; BloodCancerDiscovery;Zhao et al. 2022; JNCI;Drosos et al. 2022; MolecularCell;Graca et al. 2022; NatCommun; Kudo to Wojciech, co-first author Qi et al. 2022; JPathol
New paper! Wang et al. 2021 published in Life Sci. Alliance: PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands. Kudo to Wojciech, first co-first author with St. Jude PIs