Publications

2021:3

1. Journal of Experimen

   Foxp3 Enhancers Synergize to Maximize Regulatory T Cell Suppressive Capacity

   Zong Xinying, Hao Xiaolei, Xu Beisi, Crawford Jeremy Chase, Wright Shaela, Li Jun, Zhang Yang, Bai Lu, He Minghong, Jiang Menglin, Fan Yiping, Connelly Jon P., Pruett-Miller Shondra M., Berns Hartmut, Janke Laura, Li Chunliang, Feng Yongqiang

   Journal of Experimental Medicine 2021

   Abstract DOI GEO:Mouse_WGSB.CutRun.ATAC.TCR.CaptureC

   T reg cells bearing a diverse antigen receptor repertoire suppress pathogenic T cells and maintain immune homeostasis during their long lifespan. How their robust function is determined genetically remains elusive. Here, we investigate the regulatory space of the cis-regulatory elements of T reg lineage–specifying factor Foxp3. Foxp3 enhancers are known as distinct readers of environmental cues controlling T reg cell induction or lineage stability. However, their single deficiencies cause mild, if any, immune dysregulation, leaving the key transcriptional mechanisms determining Foxp3 expression and thereby T reg cell suppressive capacity uncertain. We examined the collective activities of Foxp3 enhancers and found that they coordinate to maximize T reg cell induction, Foxp3 expression level, or lineage stability through distinct modes and that ablation of synergistic enhancers leads to lethal autoimmunity in young mice. Thus, the induction and maintenance of a diverse, stable T reg cell repertoire rely on combinatorial Foxp3 enhancers, suggesting broad, stage-specific, synergistic activities of cell-intrinsic factors and cell-extrinsic cues in determining T reg cell suppressive capacity.

2. Nat Immunol

   MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects

   Verma V., Jafarzadeh N., Boi S., Kundu S., Jiang Z., Fan Y., Lopez J., Nandre R., Zeng P., Alolaqi F., Ahmad S., Gaur P., Barry S. T., Valge-Archer V. E., Smith P. D., Banchereau J., Mkrtichyan M., Youngblood B., Rodriguez P. C., Gupta S., Khleif S. N.

   Nat Immunol 2021
3. Blood

   FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis

   Xu P., Scott D. C., Xu B., Yao Y., Feng R., Cheng L., Mayberry K., Wang Y. D., Bi W., Palmer L. E., King M. T., Wang H., Li Y., Fan Y., Alpi A. F., Li C., Peng J., Papizan J., Pruett-Miller S. M., Spallek R., Bassermann F., Cheng Y., Schulman B. A., Weiss M. J.

   Blood 2021

2020:10

1. JCI Insight

   MyD88/CD40 signaling retains CAR T cells in a less differentiated state

   Prinzing B., Schreiner P., Bell M., Fan Y., Krenciute G., Gottschalk S.

   JCI Insight 2020
2. Nat Commun

   Ybx1 fine-tunes PRC2 activities to control embryonic brain development

   Evans M. K., Matsui Y., Xu B., Willis C., Loome J., Milburn L., Fan Y., Pagala V., Peng J. C.

   Nat Commun 2020
3. Blood Cancer Discov

   Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia

   Waanders E., Gu Z., Dobson S. M., Antić Ž., Crawford J. C., Ma X., Edmonson M. N., Payne-Turner D., Vorst M., Jongmans M. C. J., McGuire I., Zhou X., Wang J., Shi L., Pounds S., Pei D., Cheng C., Song G., Fan Y., Shao Y., Rusch M., McCastlain K., Yu J., Boxtel R., Blokzijl F., Iacobucci I., Roberts K. G., Wen J., Wu G., Ma J., Easton J., Neale G., Olsen S. R., Nichols K. E., Pui C. H., Zhang J., Evans W. E., Relling M. V., Yang J. J., Thomas P. G., Dick J. E., Kuiper R. P., Mullighan C. G.

   Blood Cancer Discov 2020
4. Nat Immunol

   Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes

   Abdelsamed H. A., Zebley C. C., Nguyen H., Rutishauser R. L., Fan Y., Ghoneim H. E., Crawford J. C., Alfei F., Alli S., Ribeiro S. P., Castellaw A. H., McGargill M. A., Jin H., Boi S. K., Speake C., Serti E., Turka L. A., Busch M. E., Stone M., Deeks S. G., Sekaly R. P., Zehn D., James E. A., Nepom G. T., Youngblood B.

   Nat Immunol 2020
5. Elife

   The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth

   Mondal B., Jin H., Kallappagoudar S., Sedkov Y., Martinez T., Sentmanat M. F., Poet G. J., Li C., Fan Y., Pruett-Miller S. M., Herz H. M.

   Elife 2020
6. Nat Immunol

   Developmental plasticity allows outside-in immune responses by resident memory T cells

   Fonseca R., Beura L. K., Quarnstrom C. F., Ghoneim H. E., Fan Y., Zebley C. C., Scott M. C., Fares-Frederickson N. J., Wijeyesinghe S., Thompson E. A., Silva H., Vezys V., Youngblood B., Masopust D.

   Nat Immunol 2020
7. Leukemia

   A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia

   Elsayed A. H., Rafiee R., Cao X., Raimondi S., Downing J. R., Ribeiro R., Fan Y., Gruber T. A., Baker S., Klco J., Rubnitz J. E., Pounds S., Lamba J. K.

   Leukemia 2020
8. Nat Commun

   MYCN amplification and ATRX mutations are incompatible in neuroblastoma

   Zeineldin M., Federico S., Chen X., Fan Y., Xu B., Stewart E., Zhou X., Jeon J., Griffiths L., Nguyen R., Norrie J., Easton J., Mulder H., Yergeau D., Liu Y., Wu J., Van Ryn C., Naranjo A., Hogarty M. D., Kamiński M. M., Valentine M., Pruett-Miller S. M., Pappo A., Zhang J., Clay M. R., Bahrami A., Vogel P., Lee S., Shelat A., Sarthy J. F., Meers M. P., George R. E., Mardis E. R., Wilson R. K., Henikoff S., Downing J. R., Dyer M. A.

   Nat Commun 2020
9. Bioinformatics

   ChIPseqSpikeInFree: a ChIP-seq normalization approach to reveal global changes in histone modifications without spike-in

   Jin H., Kasper L. H., Larson J. D., Wu G., Baker S. J., Zhang J., Fan Y.

   Bioinformatics 2020
10. Genes Dev

    Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis

    Robles-Murguia M., Rao D., Finkelstein D., Xu B., Fan Y., Demontis F.

    Genes Dev 2020

2019:8

1. Genome Res

   Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations

   Hunt L. C., Jiao J., Wang Y. D., Finkelstein D., Rao D., Curley M., Robles-Murguia M., Shirinifard A., Pagala V. R., Peng J., Fan Y., Demontis F.

   Genome Res 2019
2. Cell Rep

   A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice

   Hunt L. C., Stover J., Haugen B., Shaw T. I., Li Y., Pagala V. R., Finkelstein D., Barton E. R., Fan Y., Labelle M., Peng J., Demontis F.

   Cell Rep 2019
3. Nature

   TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection

   Alfei F., Kanev K., Hofmann M., Wu M., Ghoneim H. E., Roelli P., Utzschneider D. T., Hoesslin M., Cullen J. G., Fan Y., Eisenberg V., Wohlleber D., Steiger K., Merkler D., Delorenzi M., Knolle P. A., Cohen C. J., Thimme R., Youngblood B., Zehn D.

   Nature 2019
4. Acta Neuropathol

   H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo

   Silveira A. B., Kasper L. H., Fan Y., Jin H., Wu G., Shaw T. I., Zhu X., Larson J. D., Easton J., Shao Y., Yergeau D. A., Rosencrance C., Boggs K., Rusch M. C., Ding L., Zhang J., Finkelstein D., Noyes R. M., Russell B. L., Xu B., Broniscer A., Wetmore C., Pounds S. B., Ellison D. W., Zhang J., Baker S. J.

   Acta Neuropathol 2019
5. Nat Neurosci

   Differentiation of human pluripotent stem cells into neurons or cortical organoids requires transcriptional co-regulation by UTX and 53BP1

   Yang X., Xu B., Mulvey B., Evans M., Jordan S., Wang Y. D., Pagala V., Peng J., Fan Y., Patel A., Peng J. C.

   Nat Neurosci 2019
6. Nature

   Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity

   Karmaus P. W. F., Chen X., Lim S. A., Herrada A. A., Nguyen T. M., Xu B., Dhungana Y., Rankin S., Chen W., Rosencrance C., Yang K., Fan Y., Cheng Y., Easton J., Neale G., Vogel P., Chi H.

   Nature 2019
7. Cancer Cell

   Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

   Larson J. D., Kasper L. H., Paugh B. S., Jin H., Wu G., Kwon C. H., Fan Y., Shaw T. I., Silveira A. B., Qu C., Xu R., Zhu X., Zhang J., Russell H. R., Peters J. L., Finkelstein D., Xu B., Lin T., Tinkle C. L., Patay Z., Onar-Thomas A., Pounds S. B., McKinnon P. J., Ellison D. W., Zhang J., Baker S. J.

   Cancer Cell 2019
8. NPJ Aging Mech Dis

   Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system

   Robles-Murguia M., Hunt L. C., Finkelstein D., Fan Y., Demontis F.

   NPJ Aging Mech Dis 2019

2018:3

1. Dev Cell

   The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

   Lavado A., Park J. Y., Paré J., Finkelstein D., Pan H., Xu B., Fan Y., Kumar R. P., Neale G., Kwak Y. D., McKinnon P. J., Johnson R. L., Cao X.

   Dev Cell 2018
2. iScience

   KDM5A Regulates a Translational Program that Controls p53 Protein Expression

   Hu D., Jablonowski C., Cheng P. H., AlTahan A., Li C., Wang Y., Palmer L., Lan C., Sun B., Abu-Zaid A., Fan Y., Brimble M., Gamboa N. T., Kumbhar R. C., Yanishevski D., Miller K. M., Kang G., Zambetti G. P., Chen T., Yan Q., Davidoff A. M., Yang J.

   iScience 2018
3. Cancer Cell

   Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses

   Stewart E., McEvoy J., Wang H., Chen X., Honnell V., Ocarz M., Gordon B., Dapper J., Blankenship K., Yang Y., Li Y., Shaw T. I., Cho J. H., Wang X., Xu B., Gupta P., Fan Y., Liu Y., Rusch M., Griffiths L., Jeon J., Freeman B. B., Clay M. R., Pappo A., Easton J., Shurtleff S., Shelat A., Zhou X., Boggs K., Mulder H., Yergeau D., Bahrami A., Mardis E. R., Wilson R. K., Zhang J., Peng J., Downing J. R., Dyer M. A.

   Cancer Cell 2018

2017:6

1. Nature

   Effector CD8 T cells dedifferentiate into long-lived memory cells

   Youngblood B., Hale J. S., Kissick H. T., Ahn E., Xu X., Wieland A., Araki K., West E. E., Ghoneim H. E., Fan Y., Dogra P., Davis C. W., Konieczny B. T., Antia R., Cheng X., Ahmed R.

   Nature 2017
2. Nat Commun

   An unexpected protein interaction promotes drug resistance in leukemia

   Pitre A., Ge Y., Lin W., Wang Y., Fukuda Y., Temirov J., Phillips A. H., Peters J. L., Fan Y., Ma J., Nourse A., Sinha C., Lin H., Kriwacki R., Downing J. R., Gruber T. A., Centonze V. E., Naren A. P., Chen T., Schuetz J. D.

   Nat Commun 2017
3. JCI Insight

   Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis

   Fukuda Y., Wang Y., Lian S., Lynch J., Nagai S., Fanshawe B., Kandilci A., Janke L. J., Neale G., Fan Y., Sorrentino B. P., Roussel M. F., Grosveld G., Schuetz J. D.

   JCI Insight 2017
4. Cell

   De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation

   Ghoneim H. E., Fan Y., Moustaki A., Abdelsamed H. A., Dash P., Dogra P., Carter R., Awad W., Neale G., Thomas P. G., Youngblood B.

   Cell 2017
5. J Exp Med

   Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis

   Abdelsamed H. A., Moustaki A., Fan Y., Dogra P., Ghoneim H. E., Zebley C. C., Triplett B. M., Sekaly R. P., Youngblood B.

   J Exp Med 2017
6. Cell Rep

   Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma

   Vo B. T., Li C., Morgan M. A., Theurillat I., Finkelstein D., Wright S., Hyle J., Smith S. M. C., Fan Y., Wang Y. D., Wu G., Orr B. A., Northcott P. A., Shilatifard A., Sherr C. J., Roussel M. F.

   Cell Rep 2017

2016:6

1. PLoS Genet

   c-Fos Repression by Piwi Regulates Drosophila Ovarian Germline Formation and Tissue Morphogenesis

   Klein J. D., Qu C., Yang X., Fan Y., Tang C., Peng J. C.

   PLoS Genet 2016
2. Mol Immunol

   Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression

   Jones B. G., Penkert R. R., Xu B., Fan Y., Neale G., Gearhart P. J., Hurwitz J. L.

   Mol Immunol 2016
3. Sci Rep

   Msh2 deficiency leads to dysmyelination of the corpus callosum, impaired locomotion, and altered sensory function in mice

   Diouf B., Devaraju P., Janke L. J., Fan Y., Frase S., Eddins D., Peters J. L., Kim J., Pei D., Cheng C., Zakharenko S. S., Evans W. E.

   Sci Rep 2016
4. Cancer Chemother Pha

   Evaluation of artemisinins for the treatment of acute myeloid leukemia

   Drenberg C. D., Buaboonnam J., Orwick S. J., Hu S., Li L., Fan Y., Shelat A. A., Guy R. K., Rubnitz J., Baker S. D.

   Cancer Chemother Pharmacol 2016
5. Viral Immunol

   Hotspots for Vitamin-Steroid-Thyroid Hormone Response Elements Within Switch Regions of Immunoglobulin Heavy Chain Loci Predict a Direct Influence of Vitamins and Hormones on B Cell Class Switch Recombination

   Hurwitz J. L., Penkert R. R., Xu B., Fan Y., Partridge J. F., Maul R. W., Gearhart P. J.

   Viral Immunol 2016
6. J Invest Dermatol

   Telomerase Expression by Aberrant Methylation of the TERT Promoter in Melanoma Arising in Giant Congenital Nevi

   Fan Y., Lee S., Wu G., Easton J., Yergeau D., Dummer R., Vogel P., Kirkwood J. M., Barnhill R. L., Pappo A., Bahrami A.

   J Invest Dermatol 2016

2015:6

1. Genes Dev

   The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling

   Hunt L. C., Xu B., Finkelstein D., Fan Y., Carroll P. A., Cheng P. F., Eisenman R. N., Demontis F.

   Genes Dev 2015
2. Blood

   Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels

   Mullighan C. G., Jeha S., Pei D., Payne-Turner D., Coustan-Smith E., Roberts K. G., Waanders E., Choi J. K., Ma X., Raimondi S. C., Fan Y., Yang W., Song G., Yang J. J., Inaba H., Downing J. R., Leung W. H., Bowman W. P., Relling M. V., Evans W. E., Zhang J., Campana D., Pui C. H.

   Blood 2015
3. Drug Metab Dispos

   The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles

   Chaudhry A. S., Prasad B., Shirasaka Y., Fohner A., Finkelstein D., Fan Y., Wang S., Wu G., Aklillu E., Sim S. C., Thummel K. E., Schuetz E. G.

   Drug Metab Dispos 2015
4. Cell Stem Cell

   Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors

   Hiler D., Chen X., Hazen J., Kupriyanov S., Carroll P. A., Qu C., Xu B., Johnson D., Griffiths L., Frase S., Rodriguez A. R., Martin G., Zhang J., Jeon J., Fan Y., Finkelstein D., Eisenman R. N., Baldwin K., Dyer M. A.

   Cell Stem Cell 2015
5. Nat Genet

   NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

   Paugh S. W., Bonten E. J., Savic D., Ramsey L. B., Thierfelder W. E., Gurung P., Malireddi R. K., Actis M., Mayasundari A., Min J., Coss D. R., Laudermilk L. T., Panetta J. C., McCorkle J. R., Fan Y., Crews K. R., Stocco G., Wilkinson M. R., Ferreira A. M., Cheng C., Yang W., Karol S. E., Fernandez C. A., Diouf B., Smith C., Hicks J. K., Zanut A., Giordanengo A., Crona D., Bianchi J. J., Holmfeldt L., Mullighan C. G., Boer M. L., Pieters R., Jeha S., Dunwell T. L., Latif F., Bhojwani D., Carroll W. L., Pui C. H., Myers R. M., Guy R. K., Kanneganti T. D., Relling M. V., Evans W. E.

   Nat Genet 2015
6. JAMA

   Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia

   Diouf B., Crews K. R., Lew G., Pei D., Cheng C., Bao J., Zheng J. J., Yang W., Fan Y., Wheeler H. E., Wing C., Delaney S. M., Komatsu M., Paugh S. W., McCorkle J. R., Lu X., Winick N. J., Carroll W. L., Loh M. L., Hunger S. P., Devidas M., Pui C. H., Dolan M. E., Relling M. V., Evans W. E.

   JAMA 2015

2014:1

1. Sci Rep

   Survival analysis of infected mice reveals pathogenic variations in the genome of avian H1N1 viruses

   Koçer Z. A., Fan Y., Huether R., Obenauer J., Webby R. J., Zhang J., Webster R. G., Wu G.

   Sci Rep 2014

2013:4

1. Nat Genet

   Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse

   Perez-Andreu V., Roberts K. G., Harvey R. C., Yang W., Cheng C., Pei D., Xu H., Gastier-Foster J., E S., Lim J. Y., Chen I. M., Fan Y., Devidas M., Borowitz M. J., Smith C., Neale G., Burchard E. G., Torgerson D. G., Klussmann F. A., Villagran C. R., Winick N. J., Camitta B. M., Raetz E., Wood B., Yue F., Carroll W. L., Larsen E., Bowman W. P., Loh M. L., Dean M., Bhojwani D., Pui C. H., Evans W. E., Relling M. V., Hunger S. P., Willman C. L., Mullighan C. G., Yang J. J.

   Nat Genet 2013
2. Drug Metab Dispos

   Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s

   Chaudhry A. S., Thirumaran R. K., Yasuda K., Yang X., Fan Y., Strom S. C., Schuetz E. G.

   Drug Metab Dispos 2013
3. J Natl Cancer Inst

   Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations

   Xu H., Yang W., Perez-Andreu V., Devidas M., Fan Y., Cheng C., Pei D., Scheet P., Burchard E. G., Eng C., Huntsman S., Torgerson D. G., Dean M., Winick N. J., Martin P. L., Camitta B. M., Bowman W. P., Willman C. L., Carroll W. L., Mullighan C. G., Bhojwani D., Hunger S. P., Pui C. H., Evans W. E., Relling M. V., Loh M. L., Yang J. J.

   J Natl Cancer Inst 2013
4. Blood

   Genome-wide study of methotrexate clearance replicates SLCO1B1

   Ramsey L. B., Panetta J. C., Smith C., Yang W., Fan Y., Winick N. J., Martin P. L., Cheng C., Devidas M., Pui C. H., Evans W. E., Hunger S. P., Loh M., Relling M. V.

   Blood 2013

2012:5

1. Blood

   Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia

   Yang J. J., Cheng C., Devidas M., Cao X., Campana D., Yang W., Fan Y., Neale G., Cox N., Scheet P., Borowitz M. J., Winick N. J., Martin P. L., Bowman W. P., Camitta B., Reaman G. H., Carroll W. L., Willman C. L., Hunger S. P., Evans W. E., Pui C. H., Loh M., Relling M. V.

   Blood 2012
2. Biochem Pharmacol

   Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation

   Thirumaran R. K., Lamba J. K., Kim R. B., Urquhart B. L., Gregor J. C., Chande N., Fan Y., Qi A., Cheng C., Thummel K. E., Hall S. D., Schuetz E. G.

   Biochem Pharmacol 2012
3. J Biol Chem

   ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity

   Ulrich D. L., Lynch J., Wang Y., Fukuda Y., Nachagari D., Du G., Sun D., Fan Y., Tsurkan L., Potter P. M., Rehg J. E., Schuetz J. D.

   J Biol Chem 2012
4. J Clin Oncol

   ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia

   Xu H., Cheng C., Devidas M., Pei D., Fan Y., Yang W., Neale G., Scheet P., Burchard E. G., Torgerson D. G., Eng C., Dean M., Antillon F., Winick N. J., Martin P. L., Willman C. L., Camitta B. M., Reaman G. H., Carroll W. L., Loh M., Evans W. E., Pui C. H., Hunger S. P., Relling M. V., Yang J. J.

   J Clin Oncol 2012
5. Genome Res

   Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

   Ramsey L. B., Bruun G. H., Yang W., Treviño L. R., Vattathil S., Scheet P., Cheng C., Rosner G. L., Giacomini K. M., Fan Y., Sparreboom A., Mikkelsen T. S., Corydon T. J., Pui C. H., Evans W. E., Relling M. V.

   Genome Res 2012

2011:4

1. Nat Med

   Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells

   Diouf B., Cheng Q., Krynetskaia N. F., Yang W., Cheok M., Pei D., Fan Y., Cheng C., Krynetskiy E. Y., Geng H., Chen S., Thierfelder W. E., Mullighan C. G., Downing J. R., Hsieh P., Pui C. H., Relling M. V., Evans W. E.

   Nat Med 2011
2. J Natl Cancer Inst

   Activity of the multikinase inhibitor sorafenib in combination with cytarabine in acute myeloid leukemia

   Hu S., Niu H., Inaba H., Orwick S., Rose C., Panetta J. C., Yang S., Pounds S., Fan Y., Calabrese C., Rehg J. E., Campana D., Rubnitz J. E., Baker S. D.

   J Natl Cancer Inst 2011
3. Nat Genet

   Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia

   Yang J. J., Cheng C., Devidas M., Cao X., Fan Y., Campana D., Yang W., Neale G., Cox N. J., Scheet P., Borowitz M. J., Winick N. J., Martin P. L., Willman C. L., Bowman W. P., Camitta B. M., Carroll A., Reaman G. H., Carroll W. L., Loh M., Hunger S. P., Pui C. H., Evans W. E., Relling M. V.

   Nat Genet 2011
4. Leukemia

   A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity

   Chen S. H., Yang W., Fan Y., Stocco G., Crews K. R., Yang J. J., Paugh S. W., Pui C. H., Evans W. E., Relling M. V.

   Leukemia 2011

2009:1

1. JAMA

   Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia

   Yang J. J., Cheng C., Yang W., Pei D., Cao X., Fan Y., Pounds S. B., Neale G., Treviño L. R., French D., Campana D., Downing J. R., Evans W. E., Pui C. H., Devidas M., Bowman W. P., Camitta B. M., Willman C. L., Davies S. M., Borowitz M. J., Carroll W. L., Hunger S. P., Relling M. V.

   JAMA 2009

2008:2

1. Clin Pharmacol Ther

   Etoposide sensitivity does not predict MLL rearrangements or risk of therapy-related acute myeloid leukemia

   Yang J., Bogni A., Cheng C., Bleibel W. K., Cai X., Fan Y., Yang W., Rocha J. C., Pei D., Liu W., Dolan M. E., Pui C. H., Relling M. V.

   Clin Pharmacol Ther 2008
2. PLoS One

   Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs

   French D., Yang W., Hamilton L. H., Neale G., Fan Y., Downing J. R., Cox N. J., Pui C. H., Evans W. E., Relling M. V.

   PLoS One 2008

2007:1

1. Leukemia

   Genome scan implicates adhesion biological pathways in secondary leukemia

   Hartford C., Yang W., Cheng C., Fan Y., Liu W., Treviño L., Pounds S., Neale G., Raimondi S. C., Bogni A., Dolan M. E., Pui C. H., Relling M. V.

   Leukemia 2007

2006:2

1. PLoS Genet

   A high-resolution map of Arabidopsis recombinant inbred lines by whole-genome exon array hybridization

   Singer T., Fan Y., Chang H. S., Zhu T., Hazen S. P., Briggs S. P.

   PLoS Genet 2006
2. Science

   Large-scale sequence analysis of avian influenza isolates

   Obenauer J. C., Denson J., Mehta P. K., Su X., Mukatira S., Finkelstein D. B., Xu X., Wang J., Ma J., Fan Y., Rakestraw K. M., Webster R. G., Hoffmann E., Krauss S., Zheng J., Zhang Z., Naeve C. W.

   Science 2006

2000:1

1. J Neurophysiol

   Biophysical characterization of rat caudal hypothalamic neurons: calcium channel contribution to excitability

   Fan Y. P., Horn E. M., Waldrop T. G.

   J Neurophysiol 2000

1999:1

1. J Neurophysiol

   Developmental aspects and mechanisms of rat caudal hypothalamic neuronal responses to hypoxia

   Horn E. M., Dillon G. H., Fan Y. P., Waldrop T. G.

   J Neurophysiol 1999

1995:1

1. Sheng Li Xue Bao

   [The role of accumbens nucleus in the inhibitory effect of somatic afferent inputs on the defence cardiovascular response and its mechanism]

   Fan Y. P., Zhang R. B.

   Sheng Li Xue Bao 1995