Yiping Fan

Associate Director (Transcriptomics)
St. Jude Profile
NCBI Bibliography


Dr. Yiping is a associate director of Center for Applied Bioinformatics at St. Jude Children’s Research Hospital. His research interests include Bioinformatics method development and optimization, biomedical application of machine learning, epigenetic regulation of T-cell functions and cancer immunotherapy


  • PhD, Bioengineering, University of California at San Diego
  • MS, Biophyics and physiology, University of Illinois at Urbana Champaign
  • BS, Biomedical Engineering, Zhejiang University

Professional Experience

Time Position PI/Supervisor Institution
2020- Associate Director Gang Wu St. Jude Children’s Research Hospital
2014-2019 Group Lead Jinghui Zhang St. Jude Children’s Research Hospital
2005-2014 Scientist/Senior scientist Jinghui Zhang St. Jude Children’s Research Hospital
2002-2005 Research Scientist Diversa Diversa Co


For a full list (GEO|SRA|Browser|Code) see below , or Pubmed

Full List

*denotes equal contribution


  1. Foxp3 Enhancers Synergize to Maximize Regulatory T Cell Suppressive Capacity
    Zong Xinying, Hao Xiaolei, Xu Beisi, Crawford Jeremy Chase, Wright Shaela, Li Jun, Zhang Yang, Bai Lu, He Minghong, Jiang Menglin, Fan Yiping, Connelly Jon P., Pruett-Miller Shondra M., Berns Hartmut, Janke Laura, Li Chunliang, Feng Yongqiang
    Journal of Experimental Medicine 2021

    T reg cells bearing a diverse antigen receptor repertoire suppress pathogenic T cells and maintain immune homeostasis during their long lifespan. How their robust function is determined genetically remains elusive. Here, we investigate the regulatory space of the cis-regulatory elements of T reg lineage–specifying factor Foxp3. Foxp3 enhancers are known as distinct readers of environmental cues controlling T reg cell induction or lineage stability. However, their single deficiencies cause mild, if any, immune dysregulation, leaving the key transcriptional mechanisms determining Foxp3 expression and thereby T reg cell suppressive capacity uncertain. We examined the collective activities of Foxp3 enhancers and found that they coordinate to maximize T reg cell induction, Foxp3 expression level, or lineage stability through distinct modes and that ablation of synergistic enhancers leads to lethal autoimmunity in young mice. Thus, the induction and maintenance of a diverse, stable T reg cell repertoire rely on combinatorial Foxp3 enhancers, suggesting broad, stage-specific, synergistic activities of cell-intrinsic factors and cell-extrinsic cues in determining T reg cell suppressive capacity.

  2. MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects
    Verma V., Jafarzadeh N., Boi S., Kundu S., Jiang Z., Fan Y., Lopez J., Nandre R., Zeng P., Alolaqi F., Ahmad S., Gaur P., Barry S. T., Valge-Archer V. E., Smith P. D., Banchereau J., Mkrtichyan M., Youngblood B., Rodriguez P. C., Gupta S., Khleif S. N.
    Nat Immunol 2021
  3. FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis
    Xu P., Scott D. C., Xu B., Yao Y., Feng R., Cheng L., Mayberry K., Wang Y. D., Bi W., Palmer L. E., King M. T., Wang H., Li Y., Fan Y., Alpi A. F., Li C., Peng J., Papizan J., Pruett-Miller S. M., Spallek R., Bassermann F., Cheng Y., Schulman B. A., Weiss M. J.
    Blood 2021


  1. MyD88/CD40 signaling retains CAR T cells in a less differentiated state
    Prinzing B., Schreiner P., Bell M., Fan Y., Krenciute G., Gottschalk S.
    JCI Insight 2020
  2. Ybx1 fine-tunes PRC2 activities to control embryonic brain development
    Evans M. K., Matsui Y., Xu B., Willis C., Loome J., Milburn L., Fan Y., Pagala V., Peng J. C.
    Nat Commun 2020
  3. Mutational landscape and patterns of clonal evolution in relapsed pediatric acute lymphoblastic leukemia
    Waanders E., Gu Z., Dobson S. M., Antić Ž., Crawford J. C., Ma X., Edmonson M. N., Payne-Turner D., Vorst M., Jongmans M. C. J., McGuire I., Zhou X., Wang J., Shi L., Pounds S., Pei D., Cheng C., Song G., Fan Y., Shao Y., Rusch M., McCastlain K., Yu J., Boxtel R., Blokzijl F., Iacobucci I., Roberts K. G., Wen J., Wu G., Ma J., Easton J., Neale G., Olsen S. R., Nichols K. E., Pui C. H., Zhang J., Evans W. E., Relling M. V., Yang J. J., Thomas P. G., Dick J. E., Kuiper R. P., Mullighan C. G.
    Blood Cancer Discov 2020
  4. Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes
    Abdelsamed H. A., Zebley C. C., Nguyen H., Rutishauser R. L., Fan Y., Ghoneim H. E., Crawford J. C., Alfei F., Alli S., Ribeiro S. P., Castellaw A. H., McGargill M. A., Jin H., Boi S. K., Speake C., Serti E., Turka L. A., Busch M. E., Stone M., Deeks S. G., Sekaly R. P., Zehn D., James E. A., Nepom G. T., Youngblood B.
    Nat Immunol 2020
  5. The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth
    Mondal B., Jin H., Kallappagoudar S., Sedkov Y., Martinez T., Sentmanat M. F., Poet G. J., Li C., Fan Y., Pruett-Miller S. M., Herz H. M.
    Elife 2020
  6. Developmental plasticity allows outside-in immune responses by resident memory T cells
    Fonseca R., Beura L. K., Quarnstrom C. F., Ghoneim H. E., Fan Y., Zebley C. C., Scott M. C., Fares-Frederickson N. J., Wijeyesinghe S., Thompson E. A., Silva H., Vezys V., Youngblood B., Masopust D.
    Nat Immunol 2020
  7. A six-gene leukemic stem cell score identifies high risk pediatric acute myeloid leukemia
    Elsayed A. H., Rafiee R., Cao X., Raimondi S., Downing J. R., Ribeiro R., Fan Y., Gruber T. A., Baker S., Klco J., Rubnitz J. E., Pounds S., Lamba J. K.
    Leukemia 2020
  8. MYCN amplification and ATRX mutations are incompatible in neuroblastoma
    Zeineldin M., Federico S., Chen X., Fan Y., Xu B., Stewart E., Zhou X., Jeon J., Griffiths L., Nguyen R., Norrie J., Easton J., Mulder H., Yergeau D., Liu Y., Wu J., Van Ryn C., Naranjo A., Hogarty M. D., Kamiński M. M., Valentine M., Pruett-Miller S. M., Pappo A., Zhang J., Clay M. R., Bahrami A., Vogel P., Lee S., Shelat A., Sarthy J. F., Meers M. P., George R. E., Mardis E. R., Wilson R. K., Henikoff S., Downing J. R., Dyer M. A.
    Nat Commun 2020
  9. ChIPseqSpikeInFree: a ChIP-seq normalization approach to reveal global changes in histone modifications without spike-in
    Jin H., Kasper L. H., Larson J. D., Wu G., Baker S. J., Zhang J., Fan Y.
    Bioinformatics 2020
  10. Muscle-derived Dpp regulates feeding initiation via endocrine modulation of brain dopamine biosynthesis
    Robles-Murguia M., Rao D., Finkelstein D., Xu B., Fan Y., Demontis F.
    Genes Dev 2020


  1. Circadian gene variants and the skeletal muscle circadian clock contribute to the evolutionary divergence in longevity across Drosophila populations
    Hunt L. C., Jiao J., Wang Y. D., Finkelstein D., Rao D., Curley M., Robles-Murguia M., Shirinifard A., Pagala V. R., Peng J., Fan Y., Demontis F.
    Genome Res 2019
  2. A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy in Drosophila and Mice
    Hunt L. C., Stover J., Haugen B., Shaw T. I., Li Y., Pagala V. R., Finkelstein D., Barton E. R., Fan Y., Labelle M., Peng J., Demontis F.
    Cell Rep 2019
  3. TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection
    Alfei F., Kanev K., Hofmann M., Wu M., Ghoneim H. E., Roelli P., Utzschneider D. T., Hoesslin M., Cullen J. G., Fan Y., Eisenberg V., Wohlleber D., Steiger K., Merkler D., Delorenzi M., Knolle P. A., Cohen C. J., Thimme R., Youngblood B., Zehn D.
    Nature 2019
  4. H3.3 K27M depletion increases differentiation and extends latency of diffuse intrinsic pontine glioma growth in vivo
    Silveira A. B., Kasper L. H., Fan Y., Jin H., Wu G., Shaw T. I., Zhu X., Larson J. D., Easton J., Shao Y., Yergeau D. A., Rosencrance C., Boggs K., Rusch M. C., Ding L., Zhang J., Finkelstein D., Noyes R. M., Russell B. L., Xu B., Broniscer A., Wetmore C., Pounds S. B., Ellison D. W., Zhang J., Baker S. J.
    Acta Neuropathol 2019
  5. Differentiation of human pluripotent stem cells into neurons or cortical organoids requires transcriptional co-regulation by UTX and 53BP1
    Yang X., Xu B., Mulvey B., Evans M., Jordan S., Wang Y. D., Pagala V., Peng J., Fan Y., Patel A., Peng J. C.
    Nat Neurosci 2019
  6. Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression
    Larson J. D., Kasper L. H., Paugh B. S., Jin H., Wu G., Kwon C. H., Fan Y., Shaw T. I., Silveira A. B., Qu C., Xu R., Zhu X., Zhang J., Russell H. R., Peters J. L., Finkelstein D., Xu B., Lin T., Tinkle C. L., Patay Z., Onar-Thomas A., Pounds S. B., McKinnon P. J., Ellison D. W., Zhang J., Baker S. J.
    Cancer Cell 2019
  7. Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity
    Karmaus P. W. F., Chen X., Lim S. A., Herrada A. A., Nguyen T. M., Xu B., Dhungana Y., Rankin S., Chen W., Rosencrance C., Yang K., Fan Y., Cheng Y., Easton J., Neale G., Vogel P., Chi H.
    Nature 2019
  8. Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system
    Robles-Murguia M., Hunt L. C., Finkelstein D., Fan Y., Demontis F.
    NPJ Aging Mech Dis 2019


  1. The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number
    Lavado A., Park J. Y., Paré J., Finkelstein D., Pan H., Xu B., Fan Y., Kumar R. P., Neale G., Kwak Y. D., McKinnon P. J., Johnson R. L., Cao X.
    Dev Cell 2018
  2. KDM5A Regulates a Translational Program that Controls p53 Protein Expression
    Hu D., Jablonowski C., Cheng P. H., AlTahan A., Li C., Wang Y., Palmer L., Lan C., Sun B., Abu-Zaid A., Fan Y., Brimble M., Gamboa N. T., Kumbhar R. C., Yanishevski D., Miller K. M., Kang G., Zambetti G. P., Chen T., Yan Q., Davidoff A. M., Yang J.
    iScience 2018
  3. Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses
    Stewart E., McEvoy J., Wang H., Chen X., Honnell V., Ocarz M., Gordon B., Dapper J., Blankenship K., Yang Y., Li Y., Shaw T. I., Cho J. H., Wang X., Xu B., Gupta P., Fan Y., Liu Y., Rusch M., Griffiths L., Jeon J., Freeman B. B., Clay M. R., Pappo A., Easton J., Shurtleff S., Shelat A., Zhou X., Boggs K., Mulder H., Yergeau D., Bahrami A., Mardis E. R., Wilson R. K., Zhang J., Peng J., Downing J. R., Dyer M. A.
    Cancer Cell 2018


  1. Effector CD8 T cells dedifferentiate into long-lived memory cells
    Youngblood B., Hale J. S., Kissick H. T., Ahn E., Xu X., Wieland A., Araki K., West E. E., Ghoneim H. E., Fan Y., Dogra P., Davis C. W., Konieczny B. T., Antia R., Cheng X., Ahmed R.
    Nature 2017
  2. An unexpected protein interaction promotes drug resistance in leukemia
    Pitre A., Ge Y., Lin W., Wang Y., Fukuda Y., Temirov J., Phillips A. H., Peters J. L., Fan Y., Ma J., Nourse A., Sinha C., Lin H., Kriwacki R., Downing J. R., Gruber T. A., Centonze V. E., Naren A. P., Chen T., Schuetz J. D.
    Nat Commun 2017
  3. Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis
    Fukuda Y., Wang Y., Lian S., Lynch J., Nagai S., Fanshawe B., Kandilci A., Janke L. J., Neale G., Fan Y., Sorrentino B. P., Roussel M. F., Grosveld G., Schuetz J. D.
    JCI Insight 2017
  4. De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation
    Ghoneim H. E., Fan Y., Moustaki A., Abdelsamed H. A., Dash P., Dogra P., Carter R., Awad W., Neale G., Thomas P. G., Youngblood B.
    Cell 2017
  5. Human memory CD8 T cell effector potential is epigenetically preserved during in vivo homeostasis
    Abdelsamed H. A., Moustaki A., Fan Y., Dogra P., Ghoneim H. E., Zebley C. C., Triplett B. M., Sekaly R. P., Youngblood B.
    J Exp Med 2017
  6. Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma
    Vo B. T., Li C., Morgan M. A., Theurillat I., Finkelstein D., Wright S., Hyle J., Smith S. M. C., Fan Y., Wang Y. D., Wu G., Orr B. A., Northcott P. A., Shilatifard A., Sherr C. J., Roussel M. F.
    Cell Rep 2017


  1. c-Fos Repression by Piwi Regulates Drosophila Ovarian Germline Formation and Tissue Morphogenesis
    Klein J. D., Qu C., Yang X., Fan Y., Tang C., Peng J. C.
    PLoS Genet 2016
  2. Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression
    Jones B. G., Penkert R. R., Xu B., Fan Y., Neale G., Gearhart P. J., Hurwitz J. L.
    Mol Immunol 2016
  3. Msh2 deficiency leads to dysmyelination of the corpus callosum, impaired locomotion, and altered sensory function in mice
    Diouf B., Devaraju P., Janke L. J., Fan Y., Frase S., Eddins D., Peters J. L., Kim J., Pei D., Cheng C., Zakharenko S. S., Evans W. E.
    Sci Rep 2016
  4. Evaluation of artemisinins for the treatment of acute myeloid leukemia
    Drenberg C. D., Buaboonnam J., Orwick S. J., Hu S., Li L., Fan Y., Shelat A. A., Guy R. K., Rubnitz J., Baker S. D.
    Cancer Chemother Pharmacol 2016
  5. Hotspots for Vitamin-Steroid-Thyroid Hormone Response Elements Within Switch Regions of Immunoglobulin Heavy Chain Loci Predict a Direct Influence of Vitamins and Hormones on B Cell Class Switch Recombination
    Hurwitz J. L., Penkert R. R., Xu B., Fan Y., Partridge J. F., Maul R. W., Gearhart P. J.
    Viral Immunol 2016
  6. Telomerase Expression by Aberrant Methylation of the TERT Promoter in Melanoma Arising in Giant Congenital Nevi
    Fan Y., Lee S., Wu G., Easton J., Yergeau D., Dummer R., Vogel P., Kirkwood J. M., Barnhill R. L., Pappo A., Bahrami A.
    J Invest Dermatol 2016


  1. The glucose-sensing transcription factor MLX promotes myogenesis via myokine signaling
    Hunt L. C., Xu B., Finkelstein D., Fan Y., Carroll P. A., Cheng P. F., Eisenman R. N., Demontis F.
    Genes Dev 2015
  2. Outcome of children with hypodiploid ALL treated with risk-directed therapy based on MRD levels
    Mullighan C. G., Jeha S., Pei D., Payne-Turner D., Coustan-Smith E., Roberts K. G., Waanders E., Choi J. K., Ma X., Raimondi S. C., Fan Y., Yang W., Song G., Yang J. J., Inaba H., Downing J. R., Leung W. H., Bowman W. P., Relling M. V., Evans W. E., Zhang J., Campana D., Pui C. H.
    Blood 2015
  3. The CYP2C19 Intron 2 Branch Point SNP is the Ancestral Polymorphism Contributing to the Poor Metabolizer Phenotype in Livers with CYP2C19*35 and CYP2C19*2 Alleles
    Chaudhry A. S., Prasad B., Shirasaka Y., Fohner A., Finkelstein D., Fan Y., Wang S., Wu G., Aklillu E., Sim S. C., Thummel K. E., Schuetz E. G.
    Drug Metab Dispos 2015
  4. Quantification of Retinogenesis in 3D Cultures Reveals Epigenetic Memory and Higher Efficiency in iPSCs Derived from Rod Photoreceptors
    Hiler D., Chen X., Hazen J., Kupriyanov S., Carroll P. A., Qu C., Xu B., Johnson D., Griffiths L., Frase S., Rodriguez A. R., Martin G., Zhang J., Jeon J., Fan Y., Finkelstein D., Eisenman R. N., Baldwin K., Dyer M. A.
    Cell Stem Cell 2015
  5. NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells
    Paugh S. W., Bonten E. J., Savic D., Ramsey L. B., Thierfelder W. E., Gurung P., Malireddi R. K., Actis M., Mayasundari A., Min J., Coss D. R., Laudermilk L. T., Panetta J. C., McCorkle J. R., Fan Y., Crews K. R., Stocco G., Wilkinson M. R., Ferreira A. M., Cheng C., Yang W., Karol S. E., Fernandez C. A., Diouf B., Smith C., Hicks J. K., Zanut A., Giordanengo A., Crona D., Bianchi J. J., Holmfeldt L., Mullighan C. G., Boer M. L., Pieters R., Jeha S., Dunwell T. L., Latif F., Bhojwani D., Carroll W. L., Pui C. H., Myers R. M., Guy R. K., Kanneganti T. D., Relling M. V., Evans W. E.
    Nat Genet 2015
  6. Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia
    Diouf B., Crews K. R., Lew G., Pei D., Cheng C., Bao J., Zheng J. J., Yang W., Fan Y., Wheeler H. E., Wing C., Delaney S. M., Komatsu M., Paugh S. W., McCorkle J. R., Lu X., Winick N. J., Carroll W. L., Loh M. L., Hunger S. P., Devidas M., Pui C. H., Dolan M. E., Relling M. V., Evans W. E.
    JAMA 2015


  1. Survival analysis of infected mice reveals pathogenic variations in the genome of avian H1N1 viruses
    Koçer Z. A., Fan Y., Huether R., Obenauer J., Webby R. J., Zhang J., Webster R. G., Wu G.
    Sci Rep 2014


  1. Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse
    Perez-Andreu V., Roberts K. G., Harvey R. C., Yang W., Cheng C., Pei D., Xu H., Gastier-Foster J., E S., Lim J. Y., Chen I. M., Fan Y., Devidas M., Borowitz M. J., Smith C., Neale G., Burchard E. G., Torgerson D. G., Klussmann F. A., Villagran C. R., Winick N. J., Camitta B. M., Raetz E., Wood B., Yue F., Carroll W. L., Larsen E., Bowman W. P., Loh M. L., Dean M., Bhojwani D., Pui C. H., Evans W. E., Relling M. V., Hunger S. P., Willman C. L., Mullighan C. G., Yang J. J.
    Nat Genet 2013
  2. Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s
    Chaudhry A. S., Thirumaran R. K., Yasuda K., Yang X., Fan Y., Strom S. C., Schuetz E. G.
    Drug Metab Dispos 2013
  3. Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations
    Xu H., Yang W., Perez-Andreu V., Devidas M., Fan Y., Cheng C., Pei D., Scheet P., Burchard E. G., Eng C., Huntsman S., Torgerson D. G., Dean M., Winick N. J., Martin P. L., Camitta B. M., Bowman W. P., Willman C. L., Carroll W. L., Mullighan C. G., Bhojwani D., Hunger S. P., Pui C. H., Evans W. E., Relling M. V., Loh M. L., Yang J. J.
    J Natl Cancer Inst 2013
  4. Genome-wide study of methotrexate clearance replicates SLCO1B1
    Ramsey L. B., Panetta J. C., Smith C., Yang W., Fan Y., Winick N. J., Martin P. L., Cheng C., Devidas M., Pui C. H., Evans W. E., Hunger S. P., Loh M., Relling M. V.
    Blood 2013


  1. Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia
    Yang J. J., Cheng C., Devidas M., Cao X., Campana D., Yang W., Fan Y., Neale G., Cox N., Scheet P., Borowitz M. J., Winick N. J., Martin P. L., Bowman W. P., Camitta B., Reaman G. H., Carroll W. L., Willman C. L., Hunger S. P., Evans W. E., Pui C. H., Loh M., Relling M. V.
    Blood 2012
  2. Intestinal CYP3A4 and midazolam disposition in vivo associate with VDR polymorphisms and show seasonal variation
    Thirumaran R. K., Lamba J. K., Kim R. B., Urquhart B. L., Gregor J. C., Chande N., Fan Y., Qi A., Cheng C., Thummel K. E., Hall S. D., Schuetz E. G.
    Biochem Pharmacol 2012
  3. ATP-dependent mitochondrial porphyrin importer ABCB6 protects against phenylhydrazine toxicity
    Ulrich D. L., Lynch J., Wang Y., Fukuda Y., Nachagari D., Du G., Sun D., Fan Y., Tsurkan L., Potter P. M., Rehg J. E., Schuetz J. D.
    J Biol Chem 2012
  4. ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia
    Xu H., Cheng C., Devidas M., Pei D., Fan Y., Yang W., Neale G., Scheet P., Burchard E. G., Torgerson D. G., Eng C., Dean M., Antillon F., Winick N. J., Martin P. L., Willman C. L., Camitta B. M., Reaman G. H., Carroll W. L., Loh M., Evans W. E., Pui C. H., Hunger S. P., Relling M. V., Yang J. J.
    J Clin Oncol 2012
  5. Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition
    Ramsey L. B., Bruun G. H., Yang W., Treviño L. R., Vattathil S., Scheet P., Cheng C., Rosner G. L., Giacomini K. M., Fan Y., Sparreboom A., Mikkelsen T. S., Corydon T. J., Pui C. H., Evans W. E., Relling M. V.
    Genome Res 2012


  1. Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells
    Diouf B., Cheng Q., Krynetskaia N. F., Yang W., Cheok M., Pei D., Fan Y., Cheng C., Krynetskiy E. Y., Geng H., Chen S., Thierfelder W. E., Mullighan C. G., Downing J. R., Hsieh P., Pui C. H., Relling M. V., Evans W. E.
    Nat Med 2011
  2. Activity of the multikinase inhibitor sorafenib in combination with cytarabine in acute myeloid leukemia
    Hu S., Niu H., Inaba H., Orwick S., Rose C., Panetta J. C., Yang S., Pounds S., Fan Y., Calabrese C., Rehg J. E., Campana D., Rubnitz J. E., Baker S. D.
    J Natl Cancer Inst 2011
  3. Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia
    Yang J. J., Cheng C., Devidas M., Cao X., Fan Y., Campana D., Yang W., Neale G., Cox N. J., Scheet P., Borowitz M. J., Winick N. J., Martin P. L., Willman C. L., Bowman W. P., Camitta B. M., Carroll A., Reaman G. H., Carroll W. L., Loh M., Hunger S. P., Pui C. H., Evans W. E., Relling M. V.
    Nat Genet 2011
  4. A genome-wide approach identifies that the aspartate metabolism pathway contributes to asparaginase sensitivity
    Chen S. H., Yang W., Fan Y., Stocco G., Crews K. R., Yang J. J., Paugh S. W., Pui C. H., Evans W. E., Relling M. V.
    Leukemia 2011


  1. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia
    Yang J. J., Cheng C., Yang W., Pei D., Cao X., Fan Y., Pounds S. B., Neale G., Treviño L. R., French D., Campana D., Downing J. R., Evans W. E., Pui C. H., Devidas M., Bowman W. P., Camitta B. M., Willman C. L., Davies S. M., Borowitz M. J., Carroll W. L., Hunger S. P., Relling M. V.
    JAMA 2009


  1. Etoposide sensitivity does not predict MLL rearrangements or risk of therapy-related acute myeloid leukemia
    Yang J., Bogni A., Cheng C., Bleibel W. K., Cai X., Fan Y., Yang W., Rocha J. C., Pei D., Liu W., Dolan M. E., Pui C. H., Relling M. V.
    Clin Pharmacol Ther 2008
  2. Concordant gene expression in leukemia cells and normal leukocytes is associated with germline cis-SNPs
    French D., Yang W., Hamilton L. H., Neale G., Fan Y., Downing J. R., Cox N. J., Pui C. H., Evans W. E., Relling M. V.
    PLoS One 2008


  1. Genome scan implicates adhesion biological pathways in secondary leukemia
    Hartford C., Yang W., Cheng C., Fan Y., Liu W., Treviño L., Pounds S., Neale G., Raimondi S. C., Bogni A., Dolan M. E., Pui C. H., Relling M. V.
    Leukemia 2007


  1. A high-resolution map of Arabidopsis recombinant inbred lines by whole-genome exon array hybridization
    Singer T., Fan Y., Chang H. S., Zhu T., Hazen S. P., Briggs S. P.
    PLoS Genet 2006
  2. Large-scale sequence analysis of avian influenza isolates
    Obenauer J. C., Denson J., Mehta P. K., Su X., Mukatira S., Finkelstein D. B., Xu X., Wang J., Ma J., Fan Y., Rakestraw K. M., Webster R. G., Hoffmann E., Krauss S., Zheng J., Zhang Z., Naeve C. W.
    Science 2006


  1. Biophysical characterization of rat caudal hypothalamic neurons: calcium channel contribution to excitability
    Fan Y. P., Horn E. M., Waldrop T. G.
    J Neurophysiol 2000


  1. Developmental aspects and mechanisms of rat caudal hypothalamic neuronal responses to hypoxia
    Horn E. M., Dillon G. H., Fan Y. P., Waldrop T. G.
    J Neurophysiol 1999


  1. [The role of accumbens nucleus in the inhibitory effect of somatic afferent inputs on the defence cardiovascular response and its mechanism]
    Fan Y. P., Zhang R. B.
    Sheng Li Xue Bao 1995