Jason Myers

Lead Bioinformatics Analyst
GitHub
stjudecab
Email
jason.myersobfuscate#stjude.org

Overview

Jason Myers is a bioinformatician specializing in next-generation sequencing data analysis. He has performed primary differential expression analysis on hundreds of RNA-Seq data sets spanning many different organisms (including non-model), biological systems, and experimental sample paradigms (patient trials, time course studies, and synergistic effect models). Additionally, he has analyzed numerous DNA-Seq, ChIP-Seq, miRNA-Seq, single cell RNA-Seq, and Methyl-Seq data sets following these projects from inception to publication. In order to accomplish this scale of data analysis he designs, tests, and validates software and software pipelines in high-performance computing environments.

Education

  • MS, Bioinformatics, Rochester Institute of Technology, Rochester, NY
  • BS, Bioinformatics, Rochester Institute of Technology, Rochester, NY
  • AS, Computer Science, Corning Community College, Corning, NY

Professional Experience

Time Position PI/Supervisor Institution
2020 - Current Lead Bioinformatics Analyst Evadnie Rampersaud St. Jude Children’s Research Hospital, Memphis, TN

Publications

For a full list (GEO|SRA|Browser|Code) see below

Full List

*denotes equal contribution

2021:1

  1. Environmental Health
    DNA Methylation Patterns in CD 4+ T Cells of Naı̈ve and Influenza A Virus-Infected Mice Developmentally Exposed to an Aryl Hydrocarbon Receptor Ligand
    Burke Catherine G, Myers Jason R, Post Christina M, Boulé Lisbeth A, Lawrence B Paige
    Environmental Health Perspectives 2021

2020:11

  1. Leukemia
    Bone marrow mesenchymal stromal cells from acute myelogenous leukemia patients demonstrate adipogenic differentiation propensity with implications for leukemia cell support
    Azadniv Mitra, Myers Jason R, McMurray Helene R, Guo Naxin, Rock Phil, Coppage Myra L, Ashton John, Becker Michael W, Calvi Laura M, Liesveld Jane L
    Leukemia 2020
  2. bioRxiv
    Single cell transcriptomic profiling identifies molecular phenotypes of newborn human lung cells
    Bhattacharya Soumyaroop, Myers Jacquelyn, Baker Cameron, Guo Minzhe, Danopoulos Soula, Myers Jason, Bandopadhyay Gautam, Romas Stephen, Huyck Heidie L, Misra Ravi S, others
    bioRxiv 2020
  3. Pediatric research
    A novel in vitro model of primary human pediatric lung epithelial cells
    Wang Qian, Bhattacharya Soumyaroop, Mereness Jared A, Anderson Christopher, Lillis Jacquelyn A, Misra Ravi S, Romas Stephen, Huyck Heidie, Howell Amanda, Bandyopadhyay Gautam, others
    Pediatric research 2020
  4. bioRxiv
    Transcription factor PU. 1 enforces quiescence and limits hematopoietic stem cell expansion during inflammatory stress
    Chavez James S, Rabe Jennifer L, Loeffler Dirk, Higa Kelly, Hernandez Giovanny, Mills Taylor S, Ahmed Nouraiz, Gessner Rachel L, Ke Zhonghe, Idler Beau M, others
    bioRxiv 2020
  5. Infection Control &
    Genomic analysis of Clostridioides difficile in two regions reveals a diversity of strains and limited transmission
    Pecora Nicole, Holzbauer Stacy, Wang Xiong, Gu Yu, Hatwar Trupti, Dziejman Michelle, Myers Jason, DHeilly Paige, Guh Alice, Qiu Xing, others
    Infection Control & Hospital Epidemiology 2020
  6. Cancer discovery
    Monocytic subclones confer resistance to venetoclax-based therapy in patients with acute myeloid leukemia
    Pei Shanshan, Pollyea Daniel A, Gustafson Annika, Stevens Brett M, Minhajuddin Mohammad, Fu Rui, Riemondy Kent A, Gillen Austin E, Sheridan Ryan M, Kim Jihye, others
    Cancer discovery 2020
  7. BookChapter
    Single-Cell RNA-Seq Reveals Cellular and Molecular Correlates of Severe Illness in RSV-Infected Infants
    Chu C-Y, Bhattacharya S, McDavid A, Slaunwhite C, Ren Y, Anderson CS, Myers J, Falsey AR, Topham D, Caserta M, others
    2020
  8. Haematologica
    Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis
    Hernandez Giovanny, Mills Taylor S, Rabe Jennifer L, Chavez James S, Kuldanek Susan, Kirkpatrick Gregory, Noetzli Leila, Jubair Widian K, Zanche Michelle, Myers Jason R, others
    Haematologica 2020
  9. bioRxiv
    Comparative analysis of single-cell RNA Sequencing Platforms and Methods
    Ashton John M, Rehrauer Hubert, Myers Jason, Myers Jacqueline, Zanche Michelle, Balys Malene, Foox Jonathan, Mason Christopher E, Steen Robert, Kuentzel Marcy, others
    bioRxiv 2020
  10. Circulation Research
    Glutamyl-prolyl-tRNA synthetase regulates proline-rich pro-fibrotic protein synthesis during cardiac fibrosis
    Wu Jiangbin, Subbaiah Kadiam C Venkata, Xie Li Huitong, Jiang Feng, Khor Eng-Soon, Mickelsen Deanne, Myers Jason R, Tang Wai Hong Wilson, Yao Peng
    Circulation Research 2020
  11. bioRxiv
    Septins disruption controls tumor growth and enhances efficacy of Herceptin
    Singh Rakesh K, Kim Kyu Kwang, Khazan Negar, Rowswell_Turner Rachael B, Laggner Christian, Jones Aaron, Srivastava Priyanka, Hovanesian Virginia, Lamere Liz, Conley Thomas, others
    bioRxiv 2020

2019:14

  1. BookChapter
    Characterization of Neonatal Lung Cells Through Single Cell Genome Sequencing
    Bhattacharya S, Lillis J, Baker C, Guo M, Myers JR, Bandopadhyay G, Romas S, Misra R, Dutra J, Holden-Wiltse J, others
    2019
  2. Journal
    A Specific Mesenchymal Stem and Progenitor Cell (MSPC) Subpopulation with a Multi-Potent Gene Signature Is Transcriptionally Altered in the Setting of Myelodysplastic Syndrome (MDS) in Primary Human Bone Marrow Aspirates
    Fountaine Thomas J, LaMere Mark W, Byun Daniel K, Myers Jason R, Ashton John M, Liesveld Jane L, Kfoury Youmna, Scadden David T, Becker Michael W, Calvi Laura M
    2019
  3. bioRxiv
    EPRS regulates proline-rich pro-fibrotic protein synthesis during cardiac fibrosis
    Wu Jiangbin, Subbaiah Kadiam C Venkata, Xie Li Huitong, Jiang Feng, Mickelsen Deanne, Myers Jason R, Tang Wai Hong Wilson, Yao Peng
    bioRxiv 2019
  4. Journal
    Developmental Plasticity of Acute Myeloid Leukemia Mediates Resistance to Venetoclax-Based Therapy
    Pei Shanshan, Pollyea Daniel A, Gustafson Annika, Minhajuddin Mohammad, Stevens Brett M, Ye Haobin, Inguva Anagha, Amaya Maria L, Krug Anna, Jones Courtney L, others
    2019
  5. BookChapter
    Single Cell Transcriptional Profiling Defines an Intercellular Signaling Network That Organizes the Developing Coronary Vasculature
    Quijada Pearl J, Lillis Jacquelyn A, Baker Cameron, Myers Jason R, Trembley Michael A, Dirkx Ronald A, Cohen Ethan D, Ashton John M, Small Eric M
    In CIRCULATION RESEARCH 2019
  6. Cell reports
    The hematopoietic oxidase NOX2 regulates self-renewal of leukemic stem cells
    Adane Biniam, Ye Haobin, Khan Nabilah, Pei Shanshan, Minhajuddin Mohammad, Stevens Brett M, Jones Courtney L, DAlessandro Angelo, Reisz Julie A, Zaberezhnyy Vadym, others
    Cell reports 2019
  7. Journal
    A neovel in vitro model of pwrimary human pediatric lung epithelial cells
    Bandyopadhyay Kathy Donlon, Myers Jason R, Ashton John, Pryhuber Gloria S, Thomas J
    2019
  8. The FASEB Journal
    Identification and Characterization of Cellular Heterogeneity within Human Late Developmental Stage Dissociated Lung by CITE-Seq
    Bandyopadhyay Gautam, Lillis Jacquelyn, Misra Ravi S, Myers Jason R, Ashton John M, Huyck Heidie L, Krenitsky Daria, Romas Stephen T, Poole Cory J, Holden-Wiltse Jeanne, others
    The FASEB Journal 2019
  9. BookChapter
    Respiratory Epithelial Cell Regulation of Pulmonary Immune Surveillance
    Bandyopadhyay G, Huyck HL, Bhattacharya S, Misra R, Lillis J, Myers J, Romas S, Holden-Wiltse J, Ashton J, Mariani TJ, others
    2019
  10. Scientific reports
    Early life exposures shape the CD4+ T cell transcriptome, influencing proliferation, differentiation, and mitochondrial dynamics later in life
    Burke Catherine G, Myers Jason R, Boule Lisbeth A, Post Christina M, Brookes Paul S, Lawrence B Paige
    Scientific reports 2019
  11. Methods
    Defining nonsense-mediated mRNA decay intermediates in human cells
    Kurosaki Tatsuaki, Myers Jason R, Maquat Lynne E
    Methods 2019
  12. ImmunoHorizons
    Genome-wide transcriptional analysis reveals novel AhR targets that regulate dendritic cell function during influenza a virus infection
    Franchini Anthony M, Myers Jason R, Jin Guang-Bi, Shepherd David M, Lawrence B Paige
    ImmunoHorizons 2019
  13. JCI insight
    Aged marrow macrophages expand platelet-biased hematopoietic stem cells via interleukin-1B
    Frisch Benjamin J, Hoffman Corey M, Latchney Sarah E, LaMere Mark W, Myers Jason, Ashton John, Li Allison J, Saunders Jerry, others
    JCI insight 2019
  14. Gut
    ARID1A, a SWI/SNF subunit, is critical to acinar cell homeostasis and regeneration and is a barrier to transformation and epithelial-mesenchymal transition in the pancreas
    Wang Wenjia, Friedland Scott C, Guo Bing, ODell Michael R, Alexander William B, Whitney-Miller Christa L, Agostini-Vulaj Diana, Huber Aaron R, Myers Jason R, Ashton John M, others
    Gut 2019

2018:12

  1. American Journal of
    Dissociation, cellular isolation, and initial molecular characterization of neonatal and pediatric human lung tissues
    Bandyopadhyay Gautam, Huyck Heidie L, Misra Ravi S, Bhattacharya Soumyaroop, Wang Qian, Mereness Jared, Lillis Jacquelyn, Myers Jason R, Ashton John, Bushnell Timothy, others
    American Journal of Physiology-Lung Cellular and Molecular Physiology 2018
  2. Brain, behavior, and
    Developmental alcohol exposure impairs synaptic plasticity without overtly altering microglial function in mouse visual cortex
    Wong Elissa L, Lutz Nina M, Hogan Victoria A, Lamantia Cassandra E, McMurray Helene R, Myers Jason R, Ashton John M, Majewska Ania K
    Brain, behavior, and immunity 2018
  3. Blood
    Rheumatoid Arthritis Causes Hematopoietic Stem Cell Reprogramming to Maintain Functionality
    Mills Taylor, Hernandez Giovanny, Rabe Jennifer L, Kuldanek Susan, Chavez James, Kirkpatrick Greg, Noetzli Leila, Jubair Widian, Zanche Michelle, Myers Jason R, others
    Blood 2018
  4. Scientific reports
    Cell type-resolved human lung lipidome reveals cellular cooperation in lung function
    Kyle Jennifer E, Clair Geremy, Bandyopadhyay Gautam, Misra Ravi S, Zink Erika M, Bloodsworth Kent J, Shukla Anil K, Du Yina, Lillis Jacquelyn, Myers Jason R, others
    Scientific reports 2018
  5. Blood
    Specific Bone Marrow Mesenchymal Subsets in Patients with Myelodysplastic Syndromes Harbor Molecular Perturbations That Alter the Dynamics of Competition between Pre-Leukemic Clones and Normal Cells
    Kfoury Youmna, Jain Esha, Myers Jason R, Ji Fei, Sykes David B, Mercier Francois, Papazian Ani, Le Cam, Randolph Mark A, Steensma David P, others
    Blood 2018
  6. Nature structural &
    NMD-degradome sequencing reveals ribosome-bound intermediates with 3?-end non-templated nucleotides
    Kurosaki Tatsuaki, Miyoshi Keita, Myers Jason R, Maquat Lynne E
    Nature structural & molecular biology 2018
  7. ANTIMICROBIAL AGENTS
    Tolerance to Caspofungin in Candida albicans Is Associated with at Least Three Distinctive Mechanisms That Govern Expression of FKS Genes and Cell Wall Remodeling (vol 61, e00071-17, 2017)
    Yang Feng, Zhang Lulu, Wakabayashi Hironao, Myers Jason, Jiang Yuanying, Cao Yongbing, Jimenez-Ortigosa Cristina, Perlin David S, Rustchenko Elena
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2018
  8. Cell stem cell
    AMPK/FIS1-mediated mitophagy is required for self-renewal of human AML stem cells
    Pei Shanshan, Minhajuddin Mohammad, Adane Biniam, Khan Nabilah, Stevens Brett M, Mack Stephen C, Lai Sisi, Rich Jeremy N, Inguva Anagha, Shannon Kevin M, others
    Cell stem cell 2018
  9. Genes & development
    Transcriptional coactivator PGC-1αcontains a novel CBP80-binding motif that orchestrates efficient target gene expression
    Cho Hana, Rambout Xavier, Gleghorn Michael L, Nguyen Phuong Quoc Thuc, Phipps Christopher R, Miyoshi Keita, Myers Jason R, Kataoka Naoyuki, Fasan Rudi, Maquat Lynne E
    Genes & development 2018
  10. Circulation
    Mechanosensitive gene regulation by myocardin-related transcription factors is required for cardiomyocyte integrity in load-induced ventricular hypertrophy
    Trembley Michael A, Quijada Pearl, Agullo-Pascual Esperanza, Tylock Kevin M, Colpan Mert, Dirkx Jr Ronald A, Myers Jason R, Mickelsen Deanne M, Mesy Bentley Karen, Rothenberg Eli, others
    Circulation 2018
  11. BookChapter
    Complete Characterization of a Novel In Vitro Model for Human Pediatric Lung Epithelial Cells
    Wang Q, Bhattacharya S, Mereness JA, Lillis J, Misra R, Romas S, Huyck HL, Howell A, Bandyopadhyay G, Donlon K, others
    2018
  12. Scientific reports
    Transcriptional regulation on aneuploid chromosomes in diverse Candida albicans mutants
    Tucker Christopher, Bhattacharya Soumyaroop, Wakabayashi Hironao, Bellaousov Stanislav, Kravets Anatoliy, Welle Stephen L, Myers Jason, Hayes Jeffrey J, Bulger Michael, Rustchenko Elena
    Scientific reports 2018

2017:11

  1. BookChapter
    Transcriptomic Analysis Of Pediatric Human Lung Tissue And Sorted Lung Cell Types
    Misra Ravi S, Huyck Heidie, Center University of Rochester M, Ashton John M, Myers Jason R, Du Yina, Xu Yan, Whitsett Jeffrey A, Bhattacharya Soumyaroop, Chu Chinyi, others
    2017
  2. Journal of Investiga
    403 S. aureus colonization is associated with dysregulation of lipid-related genes in the nonlesional skin of AD subjects
    Kwon CW, Yoshida T, Knowlden SA, De Benedetto A, Myers JR, Leung DY, Gill SR, Thakar J, Beck LA
    Journal of Investigative Dermatology 2017
  3. JCI insight
    DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism
    Shen Jie, Wang Cuicui, Li Daofeng, Xu Taotao, Myers Jason, Ashton John M, Wang Ting, Zuscik Michael J, McAlinden Audrey, OKeefe Regis J
    JCI insight 2017
  4. Genes & development
    UPF1 helicase promotes TSN-mediated miRNA decay
    Elbarbary Reyad A, Miyoshi Keita, Hedaya Omar, Myers Jason R, Maquat Lynne E
    Genes & development 2017
  5. American Journal of
    D28 THE WEB OF OMICS: DNA, RNA, AND PROTEIN MODIFICATIONS: Transcriptomic Analysis Of Pediatric Human Lung Tissue And Sorted Lung Cell Types
    Misra RS, Huyck H, Center UM, Ashton JM, Myers JR, Du Y, Xu Y, Whitsett JA, Bhattacharya S, Chu C, others
    American Journal of Respiratory and Critical Care Medicine 2017
  6. Antimicrobial agents
    Tolerance to caspofungin in Candida albicans is associated with at least three distinctive mechanisms that govern expression of FKS genes and cell wall remodeling
    Yang Feng, Zhang Lulu, Wakabayashi Hironao, Myers Jason, Jiang Yuanying, Cao Yongbing, Jimenez-Ortigosa Cristina, Perlin David S, Rustchenko Elena
    Antimicrobial agents and chemotherapy 2017
  7. Blood
    Aging of Hematopoietic Stem Cells Is Driven By Regional Specialization of Marrow Macrophages
    Hoffman Corey M, Latchney Sarah E, LaMere Mark, Myers Jason R, Ashton John M, Li Allison J, Akwaa Frank, Rubinova Rakhil, McCabe Amanda, Smith Julianne N, others
    Blood 2017
  8. ACS chemical biology
    HIV-1 frameshift RNA-targeted triazoles inhibit propagation of replication-competent and multi-drug-resistant HIV in human cells
    Hilimire Thomas A, Chamberlain Jeffrey M, Anokhina Viktoriya, Bennett Ryan P, Swart Oliver, Myers Jason R, Ashton John M, Stewart Ryan A, Featherston Aaron L, Gates Kathleen, others
    ACS chemical biology 2017
  9. Science
    Tudor-SN–mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition
    Elbarbary Reyad A, Miyoshi Keita, Myers Jason R, Du Peicheng, Ashton John M, Tian Bin, Maquat Lynne E
    Science 2017
  10. haematologica
    Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1
    Gasparetto Maura, Pei Shanshan, Minhajuddin Mohammad, Khan Nabilah, Pollyea Daniel A, Myers Jason R, Ashton John M, Becker Michael W, Vasiliou Vasilis, Humphries Keith R, others
    haematologica 2017
  11. Blood advances
    Index case of acute myeloid leukemia in a family harboring a novel CEBPA germ line mutation
    Ram Jodi, Flamm Gabrielle, Balys Marlene, Sivagnanalingam Umayal, Rothberg Paul G, Iqbal Anwar, Myers Jason R, Corbett Anthony, Ashton John M, Mendler Jason H
    Blood advances 2017

2016:3

  1. Journal
    Bone Marrow Mesenchymal Stem Cells from Acute Myelogenous Leukemia Patients Demonstrate Adipogenic Differentiation Propensity
    Azadniv Mitra, Myers Jason R, McMurray Helene, Ashton John M, Guo Naxin, Rock Phil, Coppage Myra, Calvi Laura M, Becker Michael W, Liesveld Jane L
    2016
  2. Journal of Allergy a
    Novel Gene Signatures Observed in the Nonlesional Skin from European American Atopic Dermatitis Subjects Who Are Colonized with Staphyloccoccus Aureus
    Yoshida Takeshi, Myers Jason R, Ashton John M, De Benedetto Anna, Gill Steven R, Philpot Catherine, David Gloria, Leung Donald Y, Beck Lisa A
    Journal of Allergy and Clinical Immunology 2016
  3. Blood, The Journal o
    Evolution of acute myelogenous leukemia stem cell properties after treatment and progression
    Ho Tzu-Chieh, LaMere Mark, Stevens Brett M, Ashton John M, Myers Jason R, ODwyer Kristen M, Liesveld Jane L, Mendler Jason H, Guzman Monica, Morrissette Jennifer D, others
    Blood, The Journal of the American Society of Hematology 2016

2015:4

  1. Plos one
    Residual Disease in a Novel Xenograft Model of RUNX1-Mutated, Cytogenetically Normal Acute Myeloid Leukemia
    Sivagnanalingam Umayal, Balys Marlene, Eberhardt Allison, Wang Nancy, Myers Jason R, Ashton John M, Becker Michael W, Calvi Laura M, Mendler Jason H
    Plos one 2015
  2. PloS one
    miRge-a multiplexed method of processing small RNA-Seq data to determine MicroRNA entropy
    Baras Alexander S, Mitchell Christopher J, Myers Jason R, Gupta Simone, Weng Lien-Chun, Ashton John M, Cornish Toby C, Pandey Akhilesh, Halushka Marc K
    PloS one 2015
  3. Journal
    Distinct properties of leukemia stem cells in primary refractory acute myeloid leukemia
    Mendler Jason H, Balys Marlene, Sivagnanalingam Umayal, Eberhardt Allison, Thorne Korinne, Ho Tzu-Chieh, LaMere Mark W, Moore Samuel, McMurray Helene, Myers Jason R, others
    2015
  4. BookChapter
    Potential influence of Staphylococcus aureus clonal complex 30 genotype and transcriptome on hematogenous infections
    Sharma-Kuinkel Batu K, Mongodin Emmanuel F, Myers Jason R, Vore Kelly L, Canfield Greg S, Fraser Claire M, Rude Thomas H, Fowler Vance G, Gill Steven R
    In Open forum infectious diseases 2015

2014:1

  1. BMC research notes
    Comparison of insertion/deletion calling algorithms on human next-generation sequencing data
    Ghoneim Dalia H, Myers Jason R, Tuttle Emily, Paciorkowski Alex R
    BMC research notes 2014

2013:1

  1. Proceedings of the N
    Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians
    Edholm Eva-Stina, Saez Liz-Marie Albertorio, Gill Ann L, Gill Steven R, Grayfer Leon, Haynes Nikesha, Myers Jason R, Robert Jacques
    Proceedings of the National Academy of Sciences 2013

2012:2

  1. Bioinformatics
    ART: a next-generation sequencing read simulator
    Huang Weichun, Li Leping, Myers Jason R, Marth Gabor T
    Bioinformatics 2012
  2. Journal
    Assembly, annotation, and polymorphic characterization of the Erysiphe necator transcriptome
    Myers Jason
    2012